e faecium og1rf  (ATCC)

Journal:

Article Title: Efficacy of Telithromycin (HMR 3647) against Enterococci in a Mouse Peritonitis Model

doi:

Figure Lengend Snippet: PD 50 s of telithromycin and other antibiotics for enterococci in the mouse peritonitis model

Article Snippet: Organisms recovered from the spleens of dead mice were retested for MICs by the agar dilution method, and the MICs of TEL for these isolates were consistent with those observed prior to the inoculation. table ft1 table-wrap mode="anchored" t5 caption a7 Antibiotic Route of therapy b PD 50 (mg/kg) for a : E. faecalis E. faecium OG1RF (ATCC 47077) TX0921 Bla + Chl i Gen r Tet r TX0052 Chl i Ery r [ erm (B)] Gen r Str r V583 Chl i Ery r [ erm (B)] Tet r Van r ( vanB ) TX16 Chl i Ery r [ erm (B)] Gen r Str r Tet r TX16.01-Ery c Gen r Str r Tet r TX2465 Amp r Chl i Ery i Van r ( vanA ) TEL 0.031 0.015 4–8 8 16 0.062 0.015–0.031 p.o., 1 dose 29.7 34.9 >200 >200 >200 12.5 38.6 p.o., 2 doses — — 80 >200 168 9.35 — s.c., 1 dose 9.4 0.57 >50 >50 >50 13.6 10.4 s.c., 2 doses — — 40 25 12.5 3.12 — ERY 0.5 0.5 1,024 512–1,024 1,024 2 2–4 p.o., 1 dose >200 >200 >200 — >200 >200 — s.c., 1 dose 31.9 12.5 >200 >200 >200 27.7 35.6 Q-D 8 8 16 16 1 1 1 s.c., 1 dose — — — — >200 27.9 — s.c., 2 doses — — — — 36.5 — — i.v., 1 dose — — — — 32.1 15.2 10.2 Open in a separate window a Values in bold are MICs, (in micrograms per milliliter).

Techniques:

Journal:

Article Title: Efficacy of Telithromycin (HMR 3647) against Enterococci in a Mouse Peritonitis Model

doi:

Figure Lengend Snippet: (A) Survival and dose-response curve following therapy with TEL or ERY of peritonitis caused by E. faecalis strain TX0921 (HH22 Bla+ Genr) given by the s.c. route (single dose). (B) Survival and dose-response curve following therapy with TEL or ERY of peritonitis caused by E. faecium strain TX0016.01-Eryc given by the s.c. route (single dose).

Article Snippet: Organisms recovered from the spleens of dead mice were retested for MICs by the agar dilution method, and the MICs of TEL for these isolates were consistent with those observed prior to the inoculation. table ft1 table-wrap mode="anchored" t5 caption a7 Antibiotic Route of therapy b PD 50 (mg/kg) for a : E. faecalis E. faecium OG1RF (ATCC 47077) TX0921 Bla + Chl i Gen r Tet r TX0052 Chl i Ery r [ erm (B)] Gen r Str r V583 Chl i Ery r [ erm (B)] Tet r Van r ( vanB ) TX16 Chl i Ery r [ erm (B)] Gen r Str r Tet r TX16.01-Ery c Gen r Str r Tet r TX2465 Amp r Chl i Ery i Van r ( vanA ) TEL 0.031 0.015 4–8 8 16 0.062 0.015–0.031 p.o., 1 dose 29.7 34.9 >200 >200 >200 12.5 38.6 p.o., 2 doses — — 80 >200 168 9.35 — s.c., 1 dose 9.4 0.57 >50 >50 >50 13.6 10.4 s.c., 2 doses — — 40 25 12.5 3.12 — ERY 0.5 0.5 1,024 512–1,024 1,024 2 2–4 p.o., 1 dose >200 >200 >200 — >200 >200 — s.c., 1 dose 31.9 12.5 >200 >200 >200 27.7 35.6 Q-D 8 8 16 16 1 1 1 s.c., 1 dose — — — — >200 27.9 — s.c., 2 doses — — — — 36.5 — — i.v., 1 dose — — — — 32.1 15.2 10.2 Open in a separate window a Values in bold are MICs, (in micrograms per milliliter).

Techniques: